Students taking my virology course at the University of Leicester get a weekly newsletter containing extra links relevant to the lectures. This week the class notes are from Principles of Molecular Virology, chapter 7.
NEWS: Receptor for new coronavirus-EMC identified
The cell receptor for the coronavirus-EMC, which has so far infected 15 humans with 9 deaths, has been identified as dipeptidyl peptidase 4 (DPP4). Nice work. Evidence:
- Soluble DPP4 blocks infection of susceptible cells with CoV-EMC.
- Expression of DPP4 in non-susceptible cells renders them susceptible to infection.
- Antibody to DPP4 blocks infection of cells with CoV-EMC.
- Purified DPP4 protein binds CoV-EMC and inhibits infection.