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Tag Archives: Microscopy
New works demonstrates that integrated HIV DNA localizes at the periphery of the nucleus, revealing important insights in the nuclear biology of HIV-1. Continue reading
In basic and applied HIV research, reliable detection of viral components is crucial to monitor progression of infection. While it is routine to detect structural viral proteins in vitro for diagnostic purposes, it was previously impossible to directly and dynamically … Continue reading
Recently some of my final year virology students commented to me that it was a shame I was not still making regular MicrobiologyBytes podcasts. But as I said when I stopped posting weekly podcasts, I don’t feel that audio adds … Continue reading
The production of new HIV-1 particles is initiated at the plasma membrane where the virus polyprotein Gag assembles into a budding site, and proceeds through release of an immature virion which is subsequently transformed to the infectious virion by proteolytic … Continue reading
With its ability to observe single microbial cells at nanometre resolution, to monitor structural dynamics in response to environmental changes or drugs, and to detect and manipulate single-cell surface constituents, atomic force microscopy (AFM) provides new insight into the structure–function … Continue reading
Mimivirus appears most closely related structurally to large algal viruses such as PBCV-1 and other irridoviruses, though it possesses additional features not present in those viruses. The icosahedral capsid consists of 20 large triangular plates joined at their edges to … Continue reading
Leishmania donovani is a protozoan parasite that causes severe disease in humans with associated pathology in the spleen and liver. In experimental models of L. donovani infection, the hepatic response to infection is characterised by the presence of a focal … Continue reading
Human immunodeficiency virus (HIV) particles are formed and released at the plasma membrane of the infected cell. Researchers analyzed the dynamics of HIV assembly and release making use of fluorescently labeled HIV structural proteins. They determined that assembly of the … Continue reading
Retroviruses, such as HIV, that are already within cells are more easily transmitted when they spread through direct contact between cells than if they are floating free in the bloodstream. Researchers have recorded video of virus activity within cells that … Continue reading