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Tag Archives: Prions
Most of the major questions about prions seem now to have been answered, but one big issue still remains – how exactly do these proteins cause disease? Continue reading
A weekly newsletter for students taking my virology course. Continue reading
Crows fed on prion-infected brains from mice can transmit these infectious agents in their faeces and may play a role in the geographic spread of diseases caused by prions, such as chronic wasting disease or scrapie. The new research shows … Continue reading
Nice short review the current knowledge on five issues relevant to prion diseases: How do prions enter the body? How do prions reach the central nervous system? How do prions damage the CNS? Do mammals have an antiprion defense system? … Continue reading
Prions are self-replicating proteins which in some circumstances causes infections such as mad cow disease. Although they do not contain any nucleic acids, they do require certain co-factors to replicate. Continue reading
Propagation, mutation, and selection of prions in cultured cells. Continue reading
Prion diseases are fatal neurodegenerative disorders that are also infectious. Prions are composed of a misfolded, aggregated form of a normal cellular protein that is highly expressed in neurons. Prion-infected individuals show variability in the clinical signs and brain regions … Continue reading
Before they spread to the brain, prions often multiply in the lymphatic system –the group of organs that includes the spleen, lymph nodes, appendix and tonsils. Prions can hide in these tissues, turning individuals into silent carriers even if they … Continue reading