Tag Archives: Prions

In case you forgot – we're still fighting vCJD

A new test for asymptomatic vCJD. Continue reading

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How, exactly, do prion proteins cause disease?

Most of the major questions about prions seem now to have been answered, but one big issue still remains – how exactly do these proteins cause disease? Continue reading

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Virology Weekly Newsletter 22.03.2013 – Bumper End of Term Prion Edition!

A weekly newsletter for students taking my virology course. Continue reading

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Tis some visitor I muttered, tapping at my chamber door

Crows fed on prion-infected brains from mice can transmit these infectious agents in their faeces and may play a role in the geographic spread of diseases caused by prions, such as chronic wasting disease or scrapie. The new research shows … Continue reading

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Five Questions on Prion Diseases

Nice short review the current knowledge on five issues relevant to prion diseases: How do prions enter the body? How do prions reach the central nervous system? How do prions damage the CNS? Do mammals have an antiprion defense system? … Continue reading

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The Role of Cofactors in Prion Propagation and Infectivity

Prions are self-replicating proteins which in some circumstances causes infections such as mad cow disease. Although they do not contain any nucleic acids, they do require certain co-factors to replicate. Continue reading

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Mutation and Selection of Prions

Propagation, mutation, and selection of prions in cultured cells. Continue reading

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Biochemical Properties of Highly Neuroinvasive Prion Strains

Prion diseases are fatal neurodegenerative disorders that are also infectious. Prions are composed of a misfolded, aggregated form of a normal cellular protein that is highly expressed in neurons. Prion-infected individuals show variability in the clinical signs and brain regions … Continue reading

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Prions enter stealth mode in the spleen, causing silent infections

Before they spread to the brain, prions often multiply in the lymphatic system –the group of organs that includes the spleen, lymph nodes, appendix and tonsils. Prions can hide in these tissues, turning individuals into silent carriers even if they … Continue reading

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