Tag Archives: retrovirus

Retroviruses – NCBI Bookshelf

Earlier today I needed to look something up. You know, in a real book, not Wikipedia. Continue reading

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We know what retroviruses were up to 407 million years million years ago

The deep history of retroviruses is still obscure. Retroviruses can leave integrated copies within their hosts’ genomes, providing a fossil record for studying their long-term evolution. Endogenous forms of foamy viruses, complex retroviruses known to infect only mammalian species, appear … Continue reading

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Goats cause cancer. Yes they do. Really.

Although studies have so far failed to find an infectious agent, the evidence is now pretty clear that “professional exposure to goats” increases the risk of lung cancer.   Professional Exposure to Goats Increases the Risk of Pneumonic-Type Lung Adenocarcinoma: … Continue reading

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Novel Approaches to Inhibit HIV Entry

Human Immunodeficiency Virus (HIV) entry into target cells is a multi-step process involving binding of the viral glycoprotein, Env, to its receptor CD4 and a coreceptor – either CCR5 or CXCR4. Understanding the means by which HIV enters cells has … Continue reading

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First RNA virus-encoded miRNAs

Although the first miRNA was identified 18 years ago, it was only in 2001, with the development of technologies that allowed the efficient cDNA cloning and sequencing of small RNA species, that it became apparent that all multicellular eukaryotes encode … Continue reading

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Be thankful for retroviruses

Retroviruses have had a tremendous impact on animal genomes. At least eight percent of the human genome is comprised of retroviruses at various stages of “fossilization”. These elements represent retroviruses that have directly infected genomes of germline tissues such that … Continue reading

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Thirty Years of HIV – 1981-2011

I worked on HIV for 10 years before moving on to other things. I still maintain a close interest in the topic. 30 years – it seems like yesterday. Continue reading

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XMRV – the fight continues

In October 2009 it was reported that patients with chronic fatigue syndrome (CFS) in the USA were infected with a novel retrovirus, xenotropic murine leukaemia virus-related virus (XMRV), a virus previously linked to prostate cancer. This finding, if confirmed, would have a profound effect on the understanding and treatment of an incapacitating disease affecting millions worldwide. But does XMRV cause disease? Continue reading

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The inside out of lentivirus vectors

Lentivirus vectors bear an obvious advantage over other retrovirus vectors in that they offer the possibility to efficiently target non-dividing and differentiated cells such as neurons. But are they safe? Continue reading

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