Cell biology and disease mechanisms of Giardia species

Giardia intestinalis The eukaryotic intestinal parasite Giardia intestinalis was first described in 1681, when Antonie van Leeuwenhoek undertook a microscopic examination of his own diarrhoeal stool. Nowadays, although G. intestinalis is recognized as a major worldwide contributor to diarrhoeal disease in humans and other mammals, the disease mechanisms are still poorly understood. Owing to its reduced complexity and proposed early evolutionary divergence, G. intestinalis is used as a model eukaryotic system for studying many basic cellular processes. This review discusses recent discoveries in the molecular cell biology and pathogenesis of G. intestinalis.

Behind the smile: cell biology and disease mechanisms of Giardia species. 2010 Nature Reviews Microbiology 8, 413-422 doi:10.1038/nrmicro2317

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