Source: NHS Choices
Enterovirus infection and type 1 diabetes mellitus: systematic review and meta-analysis of observational molecular studies. BMJ 2011; 2011; 342:d35
Yes this association is not novel observation. Many pathogens are linked to the onset of disease in the near or long term. The notion of microbial cause and effect is simplistic and narrow. These kind of pathogen host interactions are a systems question and will not be resolved by linear analysis and thinking. The days of simple microbe host interactions as Koch postulated were mostly identified long ago. The kinds of diseases that confront us today will require the construction of a complex system to include microbial genetics, host genetics and epigenetics and host specific immune responses and timing. Even this model is simplistic and when applied to a large population the variances will be so great that clear multi variant associations will be only slowly revealed. Nonetheless we need to start the modeling ASAP. Yet who is funding this kind of work.?
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