Nucleoproteins and nucleocapsids of negative-strand RNA viruses

RNA viruses A hallmark of negative-strand RNA viruses is that their genomes never exist as free RNA, but instead are always assembled with many copies of a single nucleoprotein, N, to form highly stable nucleocapsids. Moreover, viral genomes are the only RNAs in infected cells that are assembled with N. The mechanism by which this specific association occurs, for both the segmented and non-segmented viruses, has recently become clearer due to our expanding knowledge of N protein and nucleocapsid structures.


Nucleoproteins and nucleocapsids of negative-strand RNA viruses. Curr Opin Microbiol. Aug 6 2011



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