Rabies is an preventable virus disease transmitted from infected animals to other warm blooded animals (zoonotic), especially human. Rabies occurs in more than 150 countries and territories. According to an estimation by WHO, almost 55,000 people die because of rabies every year. Dogs are the major reason behind this, approximately 99% human deaths caused by dog’s bites. Developing and under developing countries, both are the victims of rabies. With the post-exposure preventive regimes, 327,000 people can prevent this disease annually. This article is a short overview of the rabies virus genome, virology, symptoms, epidemiology, diagnostic methods, and the high risk countries around the globe.