Mutation and Selection of Prions

Propagation, mutation, and selection of prions in cultured cells
The finding that prions can acquire resistance to drugs has significant implications for drug design. Drugs targeted to PrPSc may have to be administered in combination, as in the case of viruses, in particular HIV. Alternatively, drugs could be targeted to bind and stabilize PrPC or, in view of the finding that ablation of PrPC, at least in animals, is not detrimental to health, to suppress its synthesis. At present no therapeutically useful drugs are available, but deepening insight into the molecular biology of prions may pave the way to novel approaches.


Mutation and Selection of Prions. (2012) PLoS Pathog 8(3): e1002582. doi:10.1371/journal.ppat.1002582


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