Transmissible spongiform encephalopathies – coming to a lab near you 

Prion-infected cultured cells do not develop visible pathological changes, and this has hampered mechanistic studies of prion-induced neurodegeneration. A new paper demonstrates for the first time an in vitro assay system that allows precise dissection of the mechanisms of prion-induced degeneration with pharmacological means. 
Prion Pathogenesis Is Faithfully Reproduced in Cerebellar Organotypic Slice Cultures. (2012) PLoS Pathog 8(11): e1002985 

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