Bacterial Flagella: Twist, Stick or Dodge

Biophysical properties of flagella The flagellum is an intricate multiprotein assembly best known for its rotational propulsion of bacteria. However, recent studies have expanded our knowledge of other functions in pathogenic contexts, particularly adherence and immune modulation, e.g. for Salmonella enterica, Campylobacter jejuni, Pseudomonas aeruginosa and Escherichia coli. Flagella-mediated adherence is important in host colonisation for several plant and animal pathogens, but the specific interactions that promote flagella binding to such diverse host tissues has remained elusive. Recent work has shown that the organelles act like probes that find favourable surface topologies to initiate binding. An emerging theme is that more general properties, such as ionic charge of repetitive binding epitopes and rotational force, allow interactions with plasma membrane components. At the same time, flagellin monomers are important inducers of plant and animal innate immunity: variation in their recognition impacts the course and outcome of infections in hosts from both kingdoms. Bacteria have evolved different strategies to evade or even promote this specific recognition, with some important differences shown for phytopathogens. These studies have provided a wider appreciation of the functions of bacterial flagella in the context of both plant and animal reservoirs.

Flagella enable pathogens to exploit or capitalise on various niches associated with the host. Although they display a range of functions, these are intrinsically linked to host colonisation and their own biophysical properties. Flagella are therefore not a virulence factor per se, but rather an early stage colonisation factor. They facilitate individual, pioneering cells to access, bind and invade new plant and animal tissues, and if successful in avoiding host recognition and clearance, to establish new colonies.

Bacterial Flagella: Twist and Stick, or Dodge across the Kingdoms. (2015) PLoS Pathog 11(1): e1004483. doi: 10.1371/journal.ppat.1004483

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