Evolution of bacterial transcription factors

Structure of a prokaryotic operon In 1962 Jacques Monod and Francois Jacob invented the operon model to explain regulation of transcription in bacteria. More recently, mainly due to the ‘omics’ revolution, we now know that things are not so tidy and ideal. For example, it is clear that pervasive transcription is widespread, and much of this may serve no readily apparent purpose. This short review focuses on transcription factors and argues they may have evolved from nucleoid-associated proteins. This would explain a large amount of recent data gleaned from high-throughput sequencing and bioinformatic analyses.

Evolution of bacterial transcription factors: how proteins take on new tasks, but do not always stop doing the old ones. Trends in Microbiology 20 May 2015 doi: 10.1016/j.tim.2015.04.009

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