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Category Archives: Microbiology
This week I’ve been talking to first year students about cell biology, discussing how much the environment of the cell varies from one site to another within the cell. Viruses “know” this and much virus replication is localized at particular … Continue reading
Every year more than 350 million people in over 120 countries contact dengue fever, which can cause symptoms ranging from aching muscles and a skin rash to life-threatening haemorrhagic fever. Researchers have struggled to create effective vaccines against dengue virus, … Continue reading
Human African trypanosomiasis – sleeping sickness – is a potentially fatal disease, which currently affects ~3,500 people in sub-Saharan Africa. The disease is caused by parasites called African trypanosomes and is spread by tsetse flies. Controlling these biting insects, combined … Continue reading
During the past ten years, several new hepatitis E viruses (HEVs) have been identiﬁed in various animal species. In parallel, the number of reports of indigenous hepatitis E in Western countries has increased as well, raising the question of what … Continue reading
Intracytoplasmic vesicular transport is well established; nucleo-cytoplasmic transport has so far been thought to be restricted to passage through the nuclear pore either passively, if size permits, or via karyopherin-mediated active transport. This limits transport in and out of the … Continue reading
Biofilms are arguably the most common state of microbial growth found in nature and in patients infected with pathogenic organisms. A feature of prokaryotic and eukaryotic biofilms is their production of an extracellular matrix. The matrix provides a protective environment … Continue reading
When a virus enters a cell it relies on the molecular machinery of its host to help it replicate. In particular, the virus relies on the ribosomes in the host cell to translate viral messenger RNA (mRNA) into polypeptides. Many … Continue reading
Herpes simplex virus 1 (HSV-1) is a neurotropic virus that establishes a life-long latent infection in the trigeminal ganglia (TG) of the infected human host. From time to time the virus asymptomatically or symptomatically reactivates from the latency stage producing … Continue reading