Tag Archives: adenovirus

Adenovirus interferes with the host DNA damage response

Adenoviruses (Ad) are everywhere, and while they pose limited threat in individuals with healthy immune systems, they cause significant disease burden in immunocompromised patients. A new study describes a mechanism by which the virus interferes with the host’s ability to … Continue reading

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Adenovirus replication – it's really all about the RNAs

Adenovirus-encoded small RNAs constitute a front-line defence against the immune system and are crucial for the survival of the virus. Continue reading

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Incoming: Tracking Virus Evolution

The ongoing dance between a virus and its host shapes how the virus evolves. Continue reading

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Adenovirus Vaccines Reinstated

I normally point to primary literature rather than other blogs here, but I’m making an exception today for two reasons. First, the History of Vaccines Blog is a consistent good read. Second, adenovirus vaccines are a fascinating case study of … Continue reading

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The transcriptome of the adenovirus infected cell

By convention, the human adenovirus replication cycle is divided into two phases, an early and a late phase, which are separated by the onset of viral DNA replication. Based on temporal changes of the gene expression pattern as revealed by … Continue reading

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Novel adenovirus infects both monkeys and humans

A novel virus that spread through a California New World monkey colony has been shown to have also infected a human researcher and a household family member, in a documented example of an adenovirus “jumping” from one species to another and remaining contagious after the jump. Continue reading

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Oncogenic activities of small DNA tumor virus transforming proteins

During the past three decades, research using the transforming proteins of small DNA tumor viruses such as adenoviruses, SV40 and human papillomaviruses has illuminated crucial cellular pathways that control proliferation and oncogenic transformation of mammalian cells. Continue reading

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Targeted Gene Delivery Using Modified Adenoviruses

Viruses are obligate intracellular parasites which have evolved as natural, biological delivery vehicles. This makes them an attractive choice of vector for various clinical gene therapy applications. Human adenoviruses (Ad) are currently the most widely used viral vectors for gene … Continue reading

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Adenovirus structure

Human adenoviruses (HAdV) are non-enveloped double-stranded DNA (dsDNA) viruses associated with acute infections. Although these infections are generally self-limiting, the re-emergence of certain HAdV types has also been linked to potentially fatal respiratory infections in both civilian and military populations. … Continue reading

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