Tag Archives: arenavirus

How do you study the pathogenesis of Lassa fever virus? (hint – very, very carefully)

How do you study a virus which is so pathogenic, you are (rightly) not allowed to work with it under normal laboratory conditions? Continue reading

Advertisements
Posted in Uncategorized | Tagged , , , , , ,

Vaccination Strategies against Highly Pathogenic Arenaviruses

The family Arenaviridae contains four important species that cause severe hemorrhagic zoonoses in humans. Continue reading

Posted in Uncategorized | Tagged , , , , , , ,

The Pathogenesis of Lassa Fever

Lassa virus, an Old World arenavirus (family Arenaviridae), is the etiological agent of Lassa fever, a severe human disease that is reported in more than 100,000 patients annually in the endemic regions of West Africa with mortality rates for hospitalized … Continue reading

Posted in Uncategorized | Tagged , , , , , ,

The Curious Case of Arenavirus Entry

Arenaviruses comprise a diverse family of enveloped negative-strand RNA viruses that are endemic to specific rodent hosts worldwide. Several arenaviruses cause severe hemorrhagic fevers in humans, including Junín and Machupo viruses in South America and Lassa fever virus in western … Continue reading

Posted in Uncategorized | Tagged , , , , ,

Expression strategies of ambisense viruses

Among the negative RNA viruses, ambisense RNA viruses occupy a distinct niche. Ambisense viruses contain at least one ambisense RNA segment, i.e. an RNA that is in part of positive and in part of negative polarity. Because of this unique … Continue reading

Posted in Uncategorized | Tagged , , , , , , ,

The Anatomy of Virus Persistence

The many millions of humans who have life-long virus infections represent a major health issue for the 21st century but also a unique opportunity for investigative virologists. For persistent virus infections to endure, two ingredients are essential. The first is … Continue reading

Posted in Uncategorized | Tagged , , , , , , , , , ,

Antibodies against persistent viruses

Persistent viruses such as hepatitis C virus (HCV) or HIV can defeat the body’s defense system and cause devastating epidemics worldwide. Recent attempts at vaccinating against HIV have relied on the induction of specific antiviral killer T lymphocytes but have … Continue reading

Posted in Uncategorized | Tagged , , , , , , , , , , , , , , , ,

Unknown disease in South Africa identified as arenavirus infection

On 12 September 2008, a tourist guide organising safari trips in Lusaka, Zambia, was evacuated in a critical condition to Johannesburg, South Africa. She was admitted to a clinic where she died on 14 September about 10 days after the … Continue reading

Posted in Biology, Emerging disease, Health, Medicine, Microbiology, Science, Virology | Tagged , , , , , , ,

A new arenavirus associated with hemorrhagic fever

Four rodent-borne arenaviruses are known to cause hemorrhagic fever in the New World. These include Junin, Machupo, Guanarito, and Sabia viruses, which are found in rural areas of Argentina, Bolivia, Venezuela, and Brazil, respectively. In December 2003 and January 2004, … Continue reading

Posted in Biology, Health, Medicine, Microbiology, Science, Virology | Tagged | 3 Comments