Tag Archives: Biology

Siderophores – more than stealing iron

Siderophores are small molecular iron chelators that are produced by microbes and whose most notable function is to sequester iron from the host and provide this essential metal nutrient to microbes. Recent studies have proposed additional, noncanonical roles for siderophores, … Continue reading

Posted in Microbiology | Tagged , , ,

Drug resistance in hookworms

More than 2 billion people around the world are infected with intestinal helminths, parasitic worms that can cause disease, complicate pregnancies, and stunt the growth of children. A number of drugs are currently used to treat hookworms, one of the … Continue reading

Posted in Microbiology | Tagged , , , , ,

As I look back

Having been involved in microbiology for so long it’s sometimes difficult to see the progress we are making. When I started out as a microbiologist in the 1970s the impact of molecular biology on microbiology was overwhelming, even if it took … Continue reading

Posted in Microbiology | Tagged , , , , , , , | 1 Comment

Dengue vaccine reduces disease burden where dengue infections are common

The first available dengue vaccine, CYD-TDV (Dengvaxia), is estimated to reduce the burden of dengue and be potentially cost effective in settings where infections with dengue are common.   The Long-Term Safety, Public Health Impact, and Cost- Effectiveness of Routine … Continue reading

Posted in Microbiology | Tagged , , , , , , , ,

Drug Resistance Mutations Enhance Growth of Malaria Parasite

Some mutations that enable drug resistance in the malaria-causing parasite Plasmodium falciparum may also help it grow. Plasmodium falciparum is a single-celled parasite that infects the human bloodstream and causes the most severe form of malaria. Some strains of P. … Continue reading

Posted in Microbiology | Tagged , , , ,

Bugs In Space

Bacteria behave differently in space, as indicated by reports of reduced lag phase, higher final cell counts, enhanced biofilm formation, increased virulence, and reduced susceptibility to antibiotics. These phenomena are theorized, at least in part, to result from reduced mass … Continue reading

Posted in Microbiology | Tagged , , ,

Cells fight back against virus factories

This week I’ve been talking to first year students about cell biology, discussing how much the environment of the cell varies from one site to another within the cell. Viruses “know” this and much virus replication is localized at particular … Continue reading

Posted in Microbiology | Tagged , , , , , ,

Nanoparticle vaccines against dengue fever?

Every year more than 350 million people in over 120 countries contact dengue fever, which can cause symptoms ranging from aching muscles and a skin rash to life-threatening haemorrhagic fever. Researchers have struggled to create effective vaccines against dengue virus, … Continue reading

Posted in Microbiology | Tagged , , , , , , ,

The skin is a reservoir for African trypanosomes

Human African trypanosomiasis – sleeping sickness – is a potentially fatal disease, which currently affects ~3,500 people in sub-Saharan Africa. The disease is caused by parasites called African trypanosomes and is spread by tsetse flies. Controlling these biting insects, combined … Continue reading

Posted in Microbiology | Tagged , , , , , , ,