Tag Archives: CRISPR

Towards a cure for herpesvirus infection with CRISPR/Cas9

Most adults carry multiple herpesviruses. Following the initial acute infection, these viruses establish life-long infections in their hosts and cause cold sores, keratitis, genital herpes, shingles, infectious mononucleosis, and other diseases. Some herpesviruses can cause cancer in man. During the … Continue reading

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CRISPR-like ‘immune’ system discovered in giant virus

Giant mimiviruses fend off invaders using defences similar to the CRISPR system deployed by bacteria and other microorganisms. Like prokaryotes, mimiviruses are plagued by viruses known as virophages. This appears to have led to the evolution of a defence system … Continue reading

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Battling Phages: How Bacteria Defend Against Viral Attack

This short review highlights the spectrum of innate strategies used by bacteria to evade phage predation. Continue reading

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Gene editing eradicates HIV-1

More than three decades after the discovery of HIV, AIDS remains a major public health problem affecting greater than 35.3 million people worldwide. Current antiretroviral therapy fails to eradicate HIV infection, partly due to the persistence of virus reservoirs. A … Continue reading

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CRISPRs and bacterial pathogenesis

CRISPR-Cas systems have taken microbiology by storm in the last few years. Continue reading

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Remember what happened last time we "cured" AIDS?

Timothy Brown, the “Berlin patient” was freed of HIV infection via a bone marrow transfusion from a compatible CCR5Δ32 donor in 2007. Last year there was a report of a newborn baby cured by very early drug therapy. The news … Continue reading

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