Tag Archives: dengue

Flavivirus-induced antibody cross-reactivity

Understanding and manipulating the cross-reactive properties of flaviviruses has the potential to assist the development of effective broad-spectrum human vaccines against dengue virus, West Nile virus and other existing and emerging flaviviruses.
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Dengue virus fusion pathway

Dengue virus infection is a growing public health problem with up to 100 million cases annually, and neither vaccines nor effective therapies are available. To search for the ways of preventing and treating dengue infections we need to better understand … Continue reading

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What Would Dengue Do?

The incidence and geographic range of dengue and dengue hemorrhagic fever has increased dramatically in recent decades. With 2.5 billion people now living in areas at risk for epidemic transmission, dengue has become the most important mosquito-borne viral disease affecting … Continue reading

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The dengue vector Aedes aegypti

Aedes aegypti is the urban vector of dengue viruses worldwide. While climate influences the geographical distribution of this mosquito species, other factors also determine the suitability of the physical environment for this mosquito. Importantly, the close association of Ae. aegypti … Continue reading

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Population movement a critical factor in dengue virus spread

Dengue fever is a major public health problem in many tropical regions of the world. It is a vector-borne disease, transmitted most often by the mosquito Aedes aegypti. According to the WHO, the prevalence of dengue is highest in tropical … Continue reading

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Rethinking dengue hemorrhagic fever

Dengue virus infection usually causes a severe flu like illness, although symptoms may be mild in young children. DHF, however, is a severe and sometimes fatal complication of dengue virus infection that affects about half a million people every year after … Continue reading

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Pathogenesis and treatment of dengue fever

Platelet-activating factor (PAF) is a potent and versatile mediator of inflammation that is produced by numerous cell types and tissues, and particularly by leukocytes. PAF acts on a single receptor (PAFR) that may be expressed on the plasma membrane or … Continue reading

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Human movements and disease transmission

To control mosquito-borne diseases like dengue fever, researchers need to look at the behavior of people, not just the insect that transmits the disease. Vector-borne diseases constitute a largely neglected and enormous burden on public health in many resource-challenged environments, … Continue reading

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Humans, not climate, drive increased dengue risk in Australia

Aedes (Stegomyia) aegypti (Linneaus) is an important vector of dengue and other arboviruses. Despite its limited flight dispersal capability, its close association with humans and its desiccation-resistant eggs have facilitated many long distance dispersal events within and between continents, allowing … Continue reading

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