Tag Archives: Drugs

The Next Opportunity for Anti-Malaria Drugs: The Liver

Humans have suffered from the burden of malarial infections for thousands of years, and the disease has influenced human evolution and history. Our ability to counter these vulnerabilities is hampered by the modest number of drug targets and our limited understanding of parasite biology. Continue reading

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Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

The emergence of resistance against most current drugs emphasizes the need to develop new approaches to control bacterial pathogens. Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery? Continue reading

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As if it wasn't bad enough

The emergence of drug resistant tuberculosis has the potential to be a serious public health problem in Sudan and strengthened tuberculosis control and improved monitoring of therapy is needed. Continue reading

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Clinical Management of HIV Drug Resistance

Combination antiretroviral therapy for HIV-1 infection has resulted in profound reductions in viremia and is associated with marked improvements in morbidity and mortality. Therapy is not curative, however, and prolonged therapy is complicated by drug toxicity and the emergence of drug resistance. Continue reading

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WHO World Health Day

“We live in an era in which we depend on antibiotics, and other antimicrobial medicines to treat conditions that decades ago, or even a few years ago in the case of HIV/AIDS, would have proved fatal. When antimicrobial resistance – … Continue reading

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Cidofovir Activity against Poxvirus Infections

Cidofovir is an nucleoside analog approved since 1996 for clinical use with broad-spectrum activity against DNA viruses. Continue reading

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Comparison of mechanisms of drug resistance among viruses

Human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) are the most prevalent deadly chronic viral diseases. HIV is treated by small molecule inhibitors. HBV is treated by immunomodulation and small molecule inhibitors. HCV is currently … Continue reading

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Antimicrobial Peptides: Primeval Molecules or Future Drugs?

From the outside and within, we are constantly bombarded with a myriad of diverse microbial species. However, our bodies are equipped with an evolutionarily conserved innate immune defense system that allows us to thwart potential pathogens. Antimicrobial peptides (AMPs) are … Continue reading

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Antimicrobial Peptides: Primeval Molecules or Future Drugs?

From the outside and within, we are constantly bombarded with a myriad of diverse microbial species. However, our bodies are equipped with an evolutionarily conserved innate immune defense system that allows us to thwart potential pathogens. Antimicrobial peptides (AMPs) are … Continue reading

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