Tag Archives: Emerging disease

How Zika virus crosses the placenta

Zika virus (ZIKV) causes microcephaly, whereas other related pathogenic flaviviruses do not. To reach the fetal brain, a virus must be transported from the maternal to the fetal circulation, which requires crossing of the placental barrier. This study demonstrates that … Continue reading

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Zika virus and interferon

Zika virus cannot replicate in mice – unless you knock out the mouse type I interferon with antibodies. As we know, Zika can replicate all too well in humans, but the pathogenesis and cell tropism of this troubling virus is … Continue reading

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The Buzz about Honey Bee Viruses

This short review presents current understanding of the role of viruses on honey bee health and address some overarching questions in honey bee virology. Why Should I Be Concerned about Honey Bee Colony Losses and What Is Colony Collapse Disorder … Continue reading

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Assessing the global threat from Zika virus

First discovered in 1947, Zika virus (ZIKV) infection remained a little-known tropical disease until 2015, when its apparent association with a considerable increase in the incidence of microcephaly in Brazil raised alarms worldwide. There is limited information on the key … Continue reading

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Common Human Mutations That Protect against Infectious Disease

For millennia, pathogens and human hosts have engaged in a perpetual struggle for supremacy. From the earliest recorded smallpox epidemics around 1350 B.C.E to the Black Death due to Yersinia pestis in the Middle Ages and continuing to modern times … Continue reading

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Emerging Paramyxoviruses – Receptor Tropism and Zoonotic Potential

Emerging infectious disease events are dominated by zoonoses: infections that are naturally transmissible from animals to humans or vice versa. A worldwide survey of ~5,000 bat specimens identified 66 novel paramyxovirus species – more than double the existing total within … Continue reading

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Zika virus, the new kid on the block

As Europe “welcomes” Zika virus*, this short introduction by Maria Zambon is highly readable, and essential for anyone who’s been hiding under a rock for the past six months.   Zika virus, the new kid on the block. Euro Surveill. … Continue reading

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Oncolytic Virotherapy – Where Are We Going?

The last few years have seen an increased interest in immunotherapy in the treatment of malignant disease. In particular, there has been significant enthusiasm for oncolytic virotherapy, with a large amount of pre-clinical data showing promise in animal models in … Continue reading

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Interferon-γ Inhibits Ebola Virus Infection

For years I’ve been telling students to forget about type II (gamma) interferon in terms of protecting against viruses – antiviral therapy is mostly down to type I (alpha/beta) interferon. Well not in the case of Ebola virus seemingly. With … Continue reading

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