Tag Archives: Fungi

Antifungal Drug Discovery – Something Old and Something New

Invasive fungal infections are devastating. Despite state-of-the-art antifungal therapy, the mortality rates for invasive infections with the three most common species of human fungal pathogens are Candida albicans, 20%–40%; Aspergillus fumigatus, 50%–90%; and Cryptococcus neoformans, 20%–70%. Although invasive fungal infections … Continue reading

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Fungi and the Rise of Mammals

MicrobiologyBytes likes a good hypothesis – one that really makes you think, even if there’s not much actual data to support it. So here’s one for you: fungi ate the reptiles? “Here are two indisputable facts: we are living in … Continue reading

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The Developing Story of Bat White-nose Syndrome

The fungi are angry. First it was the frogs, then it was the bats. Are humans next?   Fungal Disease and the Developing Story of Bat White-nose Syndrome. (2012) PLoS Pathog 8(7): e1002779. doi:10.1371/journal.ppat.1002779 Two recently emerged cutaneous fungal diseases … Continue reading

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Immunology of fungal infections

The continuing AIDS epidemic coupled with increased usage of immunosuppressive drugs to prevent organ rejection or treat autoimmune diseases has resulted in an increase in individuals at risk for acquiring fungal diseases. These concerns highlight the need to elucidate mechanisms … Continue reading

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Hydrophobins – Unique Fungal Proteins

Microorganisms are often covered by a proteinaceous surface layer that serves as a sieve for external molecular influx, as a shield to protect microbes from external aggression, or as an aid to help microbial dispersion. In bacteria, the latter is … Continue reading

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Fungal Biofilms

In real life, microbes don’t grow as they do in the laboratory, they often grow as communities called biofilms, so it is vital that we understand them. Continue reading

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An (athlete's?) foot in the door for dermatophytes

Dermatophyte research is poised to take off. Continue reading

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Indifferent, Affectionate, or Deceitful – Lifestyles of Fungi

Fungi occupy a myriad of niches. They can be free-living (indifferent) as saprophytes recycling nutrients in the natural environment and/or have a range of relationships (affectionate and deceitful) with insect, animal, or plant hosts. Interactions with plants can be a … Continue reading

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Metatranscriptomics of eukaryotes in forest soils

What would happen if all the leaves fell off the trees and did not rot? We’d be buried under them and all plants would run out of nutrients and die, then we would starve. So the seemingly non-sexy buisness of … Continue reading

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