Tag Archives: genome

Small is beautiful

Being small lets you hide, but it also limits your choices. Continue reading

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Toward rational design of bacterial genomes

The advent of genetic engineering-the ability to edit and insert DNA into living organisms-in the latter half of the 20th century created visions of a new era of synthetic biology, where novel biological functions could be designed and implemented for useful purposes. We are witnessing an exciting revolution of scale, where technical progress allows the manipulation of genetic material at the whole genome level. Continue reading

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The rise and fall of the Mycobacterium tuberculosis genome

The evolution of one of the most devastating human pathogens, Mycobacterium tuberculosis, has captivated researchers since its discovery in 1882. But where did it come from? Continue reading

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Genome packaging in influenza virus

Influenza A virus is the prototype of the Orthomyxoviridae, and like all members of this family, the negative-sense RNA that comprises its genome is divided into separate segments. These vRNA segments share a common organisation; a long central coding region … Continue reading

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Smallpox came from Africa

Human disease attributable to variola virus (VARV), the etiologic agent of smallpox, has been reported in human populations for more than 2,000 years. VARV is unique among orthopoxviruses in that it is an exclusively human pathogen. Because it has a … Continue reading

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Mycoplasma laboratorium, the first synthetic organism

Update: The end of the world? Dr Franken-Venter? Nope Craig Venter has built a synthetic genome out of laboratory chemicals and is poised to announce the creation of the first artificial life form. A team of 20 scientists led by … Continue reading

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