Tag Archives: Herpes

Herpes simplex virus: clues to its success

Herpes simplex virus (HSV) is a very successful virus with a prevalence in the human population of 40-80% worldwide. The secret lies in adaptability. Continue reading

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MicroRNAs and Persistent Virus Infection

The recent discovery of miRNAs of viral origin has dramatically changed our view on virus-host interaction. Viral miRNAs have been shown to regulate genes of both cellular and viral origin, contributing to a favorable environment for the virus. However, the … Continue reading

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Five Questions about Viruses and MicroRNAs

MicroRNAs (miRNAs) are ~22-nt regulatory RNAs expressed by all multicellular eukaryotes. Humans encode >700 miRNAs and similar numbers are likely to exist in other mammalian species. Almost all cellular miRNAs are initially transcribed by RNA polymerase II (Pol II) as … Continue reading

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Human cytomegalovirus latency, reactivation and disease

Human cytomegalovirus (HCMV) is an opportunistic human pathogen that establishes a lifelong latent infection that can periodically reactivate which, if unchecked by a robust immune response, can result in severe disease in immuno-compromised patients. Following primary infection of healthy individuals, … Continue reading

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Virus-encoded microRNAs in herpesvirus biology

MicroRNAs regulate fundamental cellular processes in all metazoans The first discovered microRNA (miRNA), lin-4 of Caenorhabditis elegans, was found because of its role in a developmental timing defect. To date, more than 900 human miRNAs have been identified. MicroRNAs have … Continue reading

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Herpes Gladiatorum: a combative virus

Players of contact sports like rugby and wrestling can end up with an infection caused by Herpes Gladiatorum (HG), a virus belonging to the herpes family. It gets into the body through cuts and abrasions and the disease is sometimes … Continue reading

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Activation of host translational control pathways by a virus developmental switch

Regulation of gene expression at the level of mRNA translation is important for the control of numerous biological processes including cell growth, differentiation, development and the response to environmental stress. Unlike prokaryotes, the vast majority of eukaryotic mRNAs are unable … Continue reading

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Herpes Helper Activities for Adeno-Associated Virus Replication

Adeno-Associated Viruses (AAV) are human parvoviruses widely used as a recombinant vector for gene transfer in animal studies and clinical trials designed to treat acquired or inherited genetic diseases. Wild type AAV is defined as a defective virus because it … Continue reading

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