Tag Archives: Herpesviruses

Herpesviruses as Pioneers in Cell Biology

Intracytoplasmic vesicular transport is well established; nucleo-cytoplasmic transport has so far been thought to be restricted to passage through the nuclear pore either passively, if size permits, or via karyopherin-mediated active transport. This limits transport in and out of the … Continue reading

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Latency in Herpes Simplex Virus 1

Herpes simplex virus 1 (HSV-1) is a neurotropic virus that establishes a life-long latent infection in the trigeminal ganglia (TG) of the infected human host. From time to time the virus asymptomatically or symptomatically reactivates from the latency stage producing … Continue reading

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Towards a cure for herpesvirus infection with CRISPR/Cas9

Most adults carry multiple herpesviruses. Following the initial acute infection, these viruses establish life-long infections in their hosts and cause cold sores, keratitis, genital herpes, shingles, infectious mononucleosis, and other diseases. Some herpesviruses can cause cancer in man. During the … Continue reading

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Cytomegalovirus

New state of the art therapies for cytomegalovirus. Continue reading

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HSV-1 evasion of the host humoral immune system

I’ve been banging on to my final year students about how cleever heresviruses are at evading the immune response. Continue reading

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Human telomeres carry an integrated copy of human herpesvirus 6

Up to half a million people in Britain today may carry a particular form of herpesvirus 6 inherited from a parent in their genetic material. Continue reading

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Shingles vaccine works but uptake is low

A vaccine against Herpes zoster (shingles) is effective – but little used. Continue reading

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So that's what ICP0 does

DNA introduced into cells by infection or transfection is immediately coated by repressive histones and repressors. Viruses have evolved mechanisms to derepress their genes. What we know of these events is based on ChIP analyses that help identify the proteins … Continue reading

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HSV latency and reactivation in neurons

Herpesviruses use two contrasting infection strategies: productive (or lytic) replication and latency, constituting fundamentally different viral gene expression programs with contrary goals and outcomes. Latency maintains the viral genome for long periods without producing infectious progeny, but allows the virus … Continue reading

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