Tag Archives: Herpesviruses

Herpes Virus Fusion and Entry: A Story with Many Characters

Virus-cell fusion induced by enveloped viruses requires disruption of both the inner and outer layers of cellular and viral membranes. For many enveloped viruses, binding of a single surface glycoprotein to its receptor promotes pH-dependent conformational changes once within the … Continue reading

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Herpes simplex virus capsid assembly and DNA packaging

Herpes simplex virus (HSV) is an important pathogenic agent that causes recurrent oral and genital lesions, blindness and encephalitis. It is a member of the family Herpesviridae, which contains three subfamilies (alpha- beta- and gammaherpesvirinae) whose members infect humans to … Continue reading

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The sneaky herpesvirus up to some new tricks

Epstein-Barr virus (EBV) and Kaposi’s Sarcoma Associated Herpesvirus (KSHV) are DNA tumor viruses that provide risk factors for Burkitt’s lymphoma, Hodgkin’s lymphoma, nasopharyngeal carcinoma, Kaposi’s Sarcoma and post-transplant lymphoproliferative disease. EBV infection has also been associated with multiple sclerosis. Healthy … Continue reading

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Herpes simplex virus: clues to its success

Herpes simplex virus (HSV) is a very successful virus with a prevalence in the human population of 40-80% worldwide. The secret lies in adaptability. Continue reading

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Virus effects on metabolism

Human cytomegalovirus infection dramatically changes cellular metabolism by altering glucose and glutamine metabolism and fatty acid synthesis. Continue reading

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Meet the newest virus fighter: Salmonella

Interfering RNAs (RNAi) are meant to match the sequence of the messenger RNAs made from genes, and then to block or inactivate the mRNA, keeping it from being translated into a harmful protein. One of the main hurdles has been … Continue reading

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