Tag Archives: HIV/AIDS

History and origin of the HIV-1 epidemic in South Africa

HIV has spread at an alarming rate in South Africa, making it the country with the highest number of HIV infections. Several studies have investigated the histories of HIV-1 subtype C epidemics but none have done so in the context … Continue reading

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Cell-to-cell infection by HIV contributes over half of virus infection

It may be more effective to develop HIV treatments that prevent cell-to-cell infection by the virus. Continue reading

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Adipose Tissue Is a Neglected HIV Reservoir

Chronic immune activation/inflammation and viral persistence in reservoirs are important features of chronic HIV infection, even in patients receiving ART. A recent paper evaluates the involvement of adipose tissue in chronic HIV/SIV infections. Adipose tissue accounts for 15 to 20% … Continue reading

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This is not the cure for HIV

CCR5 deficiency predisposes to fatal outcomes in influenza virus infection. Continue reading

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T cell exhaustion during persistent viral infections

Why does the immune system fail to clear some virus (and other infections) and allow a state of chronic infection to occur? Continue reading

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HIV Rev – Really Exasperating Virus protein

Two papers provide a more detailed structural picture of how HIV Rev works. Continue reading

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HIV-Mediated Apoptosis: New Therapeutic Targets

This review discusses the apoptotic pathways that result in the demise of the immune system in HIV infection. Continue reading

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Why HIV Virions Have Low Numbers of Envelope Spikes: Implications for Vaccine Development

A theoretical basis why artificial virus-like particles (VPLs) with a high density of envelope spikes might make a safe and efecting prophylactic vaccine against HIV. Continue reading

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Gene editing eradicates HIV-1

More than three decades after the discovery of HIV, AIDS remains a major public health problem affecting greater than 35.3 million people worldwide. Current antiretroviral therapy fails to eradicate HIV infection, partly due to the persistence of virus reservoirs. A … Continue reading

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