Tag Archives: Immunology

This is not the cure for HIV

CCR5 deficiency predisposes to fatal outcomes in influenza virus infection. Continue reading

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Silencing the alarms: Innate immune antagonism by rotaviruses

This review discusses the structural and mechanistic basis of innate immune antagonism by two direct effectors, the Rotavirus NSP1 and VP3 proteins. It starts with a nice overview of Rotavirus biology then goes on to describe how the structural and … Continue reading

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T cell exhaustion during persistent viral infections

Why does the immune system fail to clear some virus (and other infections) and allow a state of chronic infection to occur? Continue reading

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Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?

A recent paper proposes a model which could explain the involvement of CVB as a contributory factor in diabetes. Continue reading

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Typhoid: Engage Cloaking Mechanism

Why do some strains of Salmonella gauss gastoenteritis while closely-related organisms cause thyphoid? Continue reading

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HSV-1 evasion of the host humoral immune system

I’ve been banging on to my final year students about how cleever heresviruses are at evading the immune response. Continue reading

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Why Bees Need Their AMPs

Leicester research shows for the first time that antimicrobial peptides have a functional role in anti-Crithidia defense. Continue reading

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How, exactly, do prion proteins cause disease?

Most of the major questions about prions seem now to have been answered, but one big issue still remains – how exactly do these proteins cause disease? Continue reading

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Reovirus Activates a Caspase-Independent Cell Death Pathway

Two different events in the reovirus replication cycle can injure host cells by distinct mechanisms. Continue reading

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