Tag Archives: interferon

Zika virus and interferon

Zika virus cannot replicate in mice – unless you knock out the mouse type I interferon with antibodies. As we know, Zika can replicate all too well in humans, but the pathogenesis and cell tropism of this troubling virus is … Continue reading

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How important is influenza as a human pathogen?

Pretty damn important. Continue reading

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Rotavirus Roundup

Several interesting papers on responses to rotavirus infection have been published recently, so I thought I’d round them up in one place. Continue reading

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The nucleocapsid protein of measles virus blocks host interferon response

Measles virus (MV) belongs to the genus Morbillivirus of the family Paramyxoviridae. A number of paramyxoviruses inhibit host interferon (IFN) signaling pathways in host immune systems by various mechanisms. Inhibition mechanisms have been described for many paramyxoviruses. Although there are … Continue reading

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Pathogenesis and Emergence of Arboviruses

Arboviruses are distributed worldwide and represent over 30% of all emerging infectious diseases identified in the past decade. This review describes virus interferon antagonists and common strategies that arboviruses use to counter the host innate immune response. Continue reading

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Disrupting Interferon Signaling

Given the critical role of interferons (IFNs) as a first line of defense against infection, it is not surprising that many viruses have evolved strategies to block an IFN response as a means to increase their replication efficiency. Virus-mediated inhibition … Continue reading

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Virus tricks to grid-lock the type I interferon system

The innate immune system forms the first line of defence against invading micro-organisms such as viruses. It dampens initial virus replication and ensures survival of the host until specialized adaptive responses are developed. Type I interferons (IFNs) are secreted key … Continue reading

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Hepatitis C virus controls interferon production through PKR activation

In response to invasion with bacterial or viral pathogens, cells are able to mount an immediate immune response through their ability to use specialized cellular molecules, referred to as pattern recognition receptors or PRRs, to detect unusual DNA, ssRNA or … Continue reading

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How Flaviviruses Activate and Suppress the Interferon Response

The flavivirus genus includes viruses with a remarkable ability to produce disease on a large scale. The expansion and increased endemicity of dengue and West Nile viruses in the Americas exemplifies their medical and epidemiological importance. The rapid detection of … Continue reading

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