Tag Archives: Malaria

An equal and opposite reaction

Seems like a great idea – the widespread use of insecticide coate bednets to cut the spread of malaria by mosquitoes (mostly active at night). Unfortunately nature is rarely that simple. Widespread use has driven mosquitoes to evolve resistance to … Continue reading

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Drug Resistance Mutations Enhance Growth of Malaria Parasite

Some mutations that enable drug resistance in the malaria-causing parasite Plasmodium falciparum may also help it grow. Plasmodium falciparum is a single-celled parasite that infects the human bloodstream and causes the most severe form of malaria. Some strains of P. … Continue reading

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Malaria in pregnancy alters foetal neurovascular development

A growing body of evidence has established the importance of the in utero environment on neurodevelopment and long-term cognitive and behavioral outcomes. These data suggest factors that disrupt the tightly regulated in utero environment can modify normal neurodevelopmental processes. Approximately … Continue reading

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Repeated infection with malaria makes mosquitoes more dangerous

In malaria-endemic regions, humans are often infected repeatedly with the Plasmodium parasite, and the consequences of such multiple infections are under intense study. In contrast, little is known about possible co-infection and its consequences in the Anopheles mosquitoes that transmit … Continue reading

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Let’s get things in perspective

Malaria kills thousands of times more people than Ebola virus each year. Continue reading

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Malaria infected mosquitoes are more attracted to human odor

Mosquitoes infected with the malaria parasite Plasmodium falciparum are significantly more attracted to human odors than uninfected mosquitoes. Continue reading

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Forcing your way in

Malaria, toxoplasmosis, and related diseases are caused by infection with unicellular parasites called Apicomplexa. Their name refers to the elaborate invasion machinery that occupies the apical end of the parasite cell. This apparatus allows the parasite to force its way … Continue reading

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How the malaria parasite eats lunch

The parasite Plasmodium falciparum is the causative agent of severe malaria in humans, killing somewhere between 600,000 and 1.2 million people each year. The complex life cycle includes an asexual proliferation within human erythrocytes, characterised by three distinct stages: rings, … Continue reading

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Effect of antimalarial drugs on the parasite life cycle

A paper in this week’s PLoS Medicine compares the activity of 50 current and experimental antimalarials against liver, sexual blood, and mosquito stages of selected human and nonhuman parasite species, including Plasmodium falciparum, Plasmodium berghei and Plasmodium yoelii. These results provide … Continue reading

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