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Tag Archives: miRNA
miRNAs play significant roles in different diseases. By binding to target genes, miRNAs post-transcriptionally regulate gene expression. During viral infections, miRNAs manipulate the activities of viruses and host cells. Some viral miRNAs mimic cellular miRNAs, and interfere with cellular activities. … Continue reading
The RNA silencing pathway in plants acts in part as an antiviral defense mechanism. Plant viruses have evolved to encode suppressors of RNA silencing. Plant viral RNA silencing suppressor proteins (RSS) show little sequence conservation, but act on similar key … Continue reading
The Great RNA Confusion: RNAi – miRNA – siRNA – do you know the difference? Continue reading
Adenovirus-encoded small RNAs constitute a front-line defence against the immune system and are crucial for the survival of the virus. Continue reading
MicroRNAs (miRNAs) are small RNAs that play important roles in the regulation of gene expression. Continue reading
Although the first miRNA was identified 18 years ago, it was only in 2001, with the development of technologies that allowed the efficient cDNA cloning and sequencing of small RNA species, that it became apparent that all multicellular eukaryotes encode … Continue reading
MicroRNAs (miRNAs) are the subject of enormous interest. They are small non-coding RNAs that play a regulatory role in numerous and diverse cellular processes such as immune function, apoptosis and tumorigenesis. This review focuses on a few viral miRNAs with well-defined functions and uses these examples to extrapolate general themes of viral miRNA activities including autoregulation of viral gene expression, avoidance of host defenses, and a likely important role in maintaining latent and persistent infections. Continue reading
One of the most significant recent advances in biomedical research has been the discovery of short noncoding RNAs called microRNAs (miRNAs). These regulatory RNAs provide a unique level of post-transcriptional gene regulation that modulates a range of fundamental cellular processes. Continue reading