Tag Archives: Picornavirus

Virus-resistant pigs

By genetically engineering pigs to degrade a crucial virus protein, animals can be made less susceptible to foot and mouth disease virus. Continue reading

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Why poliovirus replication has been studied for more than 50 years

It’s very rare to find a long term prospective on any science topic being published in scientific journals. Continue reading

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Escape of non-enveloped virus from intact cells

The primary mode of exit for non-enveloped viruses is cell lysis. However, more complex exit strategies are possible. Continue reading

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Poliovirus replication – many generations per cell

Viruses with RNA genomes can multiply quickly, but not very accurately. This means that errors, or mutations, occur when the RNA is copied to create new viruses. The advantage of this rapid, but mistake-filled, RNA replication process is that some … Continue reading

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Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?

A recent paper proposes a model which could explain the involvement of CVB as a contributory factor in diabetes. Continue reading

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Picornavirus interactions with cellular membranes and vesicles

The entire replication cycle of picornaviruses takes place in the cytosol. Or does it? Continue reading

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Understanding Uncoating

All we need now is a drug to inhibit virus uncoating and we’ve cured the common cold. Well, some of them maybe. Continue reading

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The Mystery of the Extra "Envelope"

Apart from H7N9, the big news last week was the report that Hepatitis A Virus cloaks itself in membranes hijacked from infected cells. Continue reading

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Tricks an IRES uses to enslave ribosomes

In eukaryotes, mRNAs are primarily translated through a cap-dependent mechanism whereby initiation factors recruit the 40S ribosomal subunit to a cap structure at the 5′ end of the mRNA. However, some viral and cellular messages initiate protein synthesis without a … Continue reading

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