Tag Archives: poxviruses

Poxvirus holds its breath

Why would a virus want to make its host cell short of oxygen? Continue reading

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Poxvirus Cell Entry: How Many Proteins Does it Take?

For many viruses, one or two proteins enable cell binding, membrane fusion and entry. The large number of proteins employed by poxviruses is unprecedented and may be related to their ability to infect a wide range of cells. There are … Continue reading

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Outbreaks of human monkeypox after cessation of smallpox vaccination

At the 64th gathering of the World Health Assembly in May 2011, a majority of delegates reaffirmed the view that the remaining stocks of variola virus, the causative agent of smallpox, should be destroyed. But consideration of precisely when that … Continue reading

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Chasing Jenner's Vaccine

Cowpox virus (CPXV) is one of the earliest described members of the genus Orthopoxvirus (OPV). Historically, researchers referred to the ailment known as cowpox and even suggested that it could provide immunity against smallpox. It was Edward Jenner’s publications in … Continue reading

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This is either a very good idea or a very bad idea – you decide

It seems like only yesterday we were on the verge of international agreement to destroy all remaing laboratory stocks of smallpox (variola) virus. So it comes as something of a surprise to find people infecting monkeys with smallpox to study the pathogenesis of the disease. Continue reading

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Should Remaining Stockpiles of Smallpox Virus Be Destroyed?

In 2011 the World Health Organization WHO plans to announce its recommendation regarding the final destruction of all known remaining smallpox virus stockpiles. Smallpox, an ancient human scourge of unparalleled destructive importance throughout most of recorded human history. Continue reading

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Avipoxviruses – biology and use as vaccine vectors

Avipoxviruses (APVs) are distributed worldwide and cause disease in domestic, pet and wild birds of many species. APVs are transmitted by aerosols and biting insects, particularly mosquitoes and arthropods and are usually named after the bird species from which they … Continue reading

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Cidofovir Activity against Poxvirus Infections

Cidofovir is an nucleoside analog approved since 1996 for clinical use with broad-spectrum activity against DNA viruses. Continue reading

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Lipid Membranes in Poxvirus Replication

The poxviruses are a family of large, complex, enveloped DNA viruses that infect a variety of vertebrate and invertebrate hosts. Poxviruses are of significance both medically and scientifically due to their wide distribution, pathogenicity, and cytoplasmic replicative life cycle. Several … Continue reading

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