Tag Archives: Prions

How prions kill neurons

Prion diseases are fatal neurodegenerative disorders that cause memory loss, impaired coordination, and abnormal movements. The molecular culprit in prion diseases is PrPSc, an infectious isoform of a host-encoded glycoprotein (PrPC) that can propagate itself by a self-templating mechanism. Whether … Continue reading

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Good Amyloid, Bad Amyloid – What’s the Difference?

It’s quite remarkable that after so many years of studying prions we still don’t have a good understanding of their pathogenesis – how do they make normal cellular proteins turn evil? This interesting article suggests that it’s not the end … Continue reading

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An anti-prion system that cures infected cells

A system to cure prion infection of cells in yeast may have applications in human diseases. Continue reading

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In case you forgot – we're still fighting vCJD

A new test for asymptomatic vCJD. Continue reading

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How, exactly, do prion proteins cause disease?

Most of the major questions about prions seem now to have been answered, but one big issue still remains – how exactly do these proteins cause disease? Continue reading

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Tis some visitor I muttered, tapping at my chamber door

Crows fed on prion-infected brains from mice can transmit these infectious agents in their faeces and may play a role in the geographic spread of diseases caused by prions, such as chronic wasting disease or scrapie. The new research shows … Continue reading

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Five Questions on Prion Diseases

Nice short review the current knowledge on five issues relevant to prion diseases: How do prions enter the body? How do prions reach the central nervous system? How do prions damage the CNS? Do mammals have an antiprion defense system? … Continue reading

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The Role of Cofactors in Prion Propagation and Infectivity

Prions are self-replicating proteins which in some circumstances causes infections such as mad cow disease. Although they do not contain any nucleic acids, they do require certain co-factors to replicate. Continue reading

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Mutation and Selection of Prions

Propagation, mutation, and selection of prions in cultured cells. Continue reading

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