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Tag Archives: Prions
Prion diseases are fatal neurodegenerative disorders that cause memory loss, impaired coordination, and abnormal movements. The molecular culprit in prion diseases is PrPSc, an infectious isoform of a host-encoded glycoprotein (PrPC) that can propagate itself by a self-templating mechanism. Whether … Continue reading
It’s quite remarkable that after so many years of studying prions we still don’t have a good understanding of their pathogenesis – how do they make normal cellular proteins turn evil? This interesting article suggests that it’s not the end … Continue reading
A system to cure prion infection of cells in yeast may have applications in human diseases. Continue reading
Most of the major questions about prions seem now to have been answered, but one big issue still remains – how exactly do these proteins cause disease? Continue reading
A weekly newsletter for students taking my virology course. Continue reading
Crows fed on prion-infected brains from mice can transmit these infectious agents in their faeces and may play a role in the geographic spread of diseases caused by prions, such as chronic wasting disease or scrapie. The new research shows … Continue reading
Nice short review the current knowledge on five issues relevant to prion diseases: How do prions enter the body? How do prions reach the central nervous system? How do prions damage the CNS? Do mammals have an antiprion defense system? … Continue reading
Prions are self-replicating proteins which in some circumstances causes infections such as mad cow disease. Although they do not contain any nucleic acids, they do require certain co-factors to replicate. Continue reading