Tag Archives: receptors

Why mice don't get MERS

Where did MERS-CoV come from and what is it likely to do next? Continue reading

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Virus receptors and the host-virus arms race

A nice short article looking at pathogen-host co-evolution. Continue reading

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Integrins modulate the infection efficiency of West Nile virus

The cellular receptors and determinants that mediate entry of WNV are unclear to date. Continue reading

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How hepatitis B virus enters liver cells

Hepaptitis B virus (HBV) likes liver cells (hepatocytes). In fact, it likes them so much it won’t grow anywhere else. The reason for this close connection is because the receptor this virus needs to infect cells is only found on … Continue reading

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Filovirus Entry: A Novelty in the Fusion World

Ebolavirus (EBOV) and Marburgvirus (MARV) that compose the filovirus family of negative strand RNA viruses infect a broad range of mammalian cells. Recent studies indicate that cellular entry of this family of viruses requires a series of cellular protein interactions … Continue reading

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Hepatitis C virus (HCV) receptor identified

New research shows that Niemann-Pick C1–like 1 (NPC1L1) cholesterol uptake receptor is an HCV cell entry factor that functions after binding, at or before fusion. Together with the facts that NPC1L1 is a cellular cholesterol receptor, the HCV particle is … Continue reading

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HIV and the CCR5 coreceptor

The C-C chemokine receptor type 5 (CCR5) is a key player in HIV infection due to its involvement in the infection process. Investigations into the role of the CCR5 coreceptor first focused on its binding to the virus and the … Continue reading

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H5N1 influenza is no longer "bird flu"

Highly pathogenic avian H5N1 influenza viruses have spread throughout Asia, Europe, and Africa, raising serious worldwide concern about their pandemic potential. Although more than 250 people have been infected with these viruses, with a high rate of mortality, the molecular … Continue reading

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