Tag Archives: retrovirus

The debt we owe to retroviruses

It was already known that genes inherited from ancient retroviruses are essential to the formation of the placenta in mammals. Now it appears that genes with retrovirus origins may also be responsible for the more developed muscle mass seen in … Continue reading

Posted in Microbiology | Tagged , , , , ,

HTLV-1 Replication: An Update

I spent more than 10 years working on HTLV, the first human retrovirus to be discovered, but it was a long time ago (propably before most of the people reading this now were born :-) It’s good to get an … Continue reading

Posted in Microbiology | Tagged , , , , , ,

What’s the host and what’s the microbe?

Weiss, R. (2015) What’s the host and what’s the microbe? The Marjory Stephenson Prize Lecture 2015. Journal of General Virology, 03 July, 2015 doi: 10.1099/jgv.0.000220 The interchange between retroviruses and their hosts is an intimate one because retroviruses integrate proviral … Continue reading

Posted in Microbiology | Tagged , , , , , ,

Solving the mystery of reverse transcription

It’s frustrating that nearly 50 years after their discovery, the steps from cytoplasmic entry until integration of the reverse transcribed genome are still mysterious. Continue reading

Posted in Microbiology | Tagged , , , , , ,

Recent developments linking retroviruses to human breast cancer

Do retroviruses cause breast cancer? Continue reading

Posted in Microbiology | Tagged , , , , , , , ,

Retroviruses – NCBI Bookshelf

Earlier today I needed to look something up. You know, in a real book, not Wikipedia. Continue reading

Posted in Uncategorized | Tagged , , , , , , ,

We know what retroviruses were up to 407 million years million years ago

The deep history of retroviruses is still obscure. Retroviruses can leave integrated copies within their hosts’ genomes, providing a fossil record for studying their long-term evolution. Endogenous forms of foamy viruses, complex retroviruses known to infect only mammalian species, appear … Continue reading

Posted in Uncategorized | Tagged , , , , , , , | 1 Comment

Goats cause cancer. Yes they do. Really.

Although studies have so far failed to find an infectious agent, the evidence is now pretty clear that “professional exposure to goats” increases the risk of lung cancer.   Professional Exposure to Goats Increases the Risk of Pneumonic-Type Lung Adenocarcinoma: … Continue reading

Posted in Uncategorized | Tagged , , , , , , , , , ,

Novel Approaches to Inhibit HIV Entry

Human Immunodeficiency Virus (HIV) entry into target cells is a multi-step process involving binding of the viral glycoprotein, Env, to its receptor CD4 and a coreceptor – either CCR5 or CXCR4. Understanding the means by which HIV enters cells has … Continue reading

Posted in Uncategorized | Tagged , , , , , , , , ,