Tag Archives: Rotavirus

Silencing the alarms: Innate immune antagonism by rotaviruses

This review discusses the structural and mechanistic basis of innate immune antagonism by two direct effectors, the Rotavirus NSP1 and VP3 proteins. It starts with a nice overview of Rotavirus biology then goes on to describe how the structural and … Continue reading

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Rotavirus Roundup

Several interesting papers on responses to rotavirus infection have been published recently, so I thought I’d round them up in one place. Continue reading

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Rotavirus vaccine for UK babies 

Rotavirus vaccine, Rotarix, will be added to the UK routine childhood vaccination schedule next year. It is estimated that the vaccine will halve the number of vomiting and diarrhoea cases caused by rotavirus and there could be 70% fewer hospital … Continue reading

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Routine rotavirus vaccination in Brazil has reduced diarrheoa deaths in children

Diarrhoeal disease, usually caused by infectious agents, is the second major cause of death in children aged under five years. Despite the targets of Millennium Development Goal 7 to half the number of people without access to clean water or improved sanitation by 2015, over one billion people worldwide do not currently have access to clean water and over two billion do not currently have access to improved sanitation. Continue reading

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Assortment and packaging of the rotavirus genome

The rotavirus (RV) genome comprises 11 segments of double-stranded RNA (dsRNA) and is contained within a non-enveloped, icosahedral particle. During assembly, a highly coordinated selective packaging mechanism ensures that progeny RV virions contain one of each genome segment. Cis-acting signals … Continue reading

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How to make a rotavirus vaccine

Group A rotaviruses (RVs) are important pathogens that cause acute, dehydrating gastroenteritis in infants and young children. The burden of disease is severe, particularly in developing countries where RV infections lead to more than 500,000 deaths annually. RVs are non-enveloped, … Continue reading

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Rotavirus vaccines for the developing world

Rotaviruses were discovered in 1972 when the virus was seen by direct electron microscopy visualization in the intestinal biopsies of children with acute diarrhoea. The authors of a new review discuss the most relevant information in the field of rotavirus … Continue reading

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