Tag Archives: Virology

How Zika virus crosses the placenta

Zika virus (ZIKV) causes microcephaly, whereas other related pathogenic flaviviruses do not. To reach the fetal brain, a virus must be transported from the maternal to the fetal circulation, which requires crossing of the placental barrier. This study demonstrates that … Continue reading

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Zika virus and interferon

Zika virus cannot replicate in mice – unless you knock out the mouse type I interferon with antibodies. As we know, Zika can replicate all too well in humans, but the pathogenesis and cell tropism of this troubling virus is … Continue reading

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Genetically engineered mosquitos resist dengue fever virus

Dengue has represented a significant public health burden for a number of decades. Given the lack of dengue-specific drugs and limited availability of licensed vaccine, new methods for prevention and control are urgently needed. Researchers investigated whether genetic manipulation of … Continue reading

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Dengue vaccine reduces disease burden where dengue infections are common

The first available dengue vaccine, CYD-TDV (Dengvaxia), is estimated to reduce the burden of dengue and be potentially cost effective in settings where infections with dengue are common.   The Long-Term Safety, Public Health Impact, and Cost- Effectiveness of Routine … Continue reading

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Cells fight back against virus factories

This week I’ve been talking to first year students about cell biology, discussing how much the environment of the cell varies from one site to another within the cell. Viruses “know” this and much virus replication is localized at particular … Continue reading

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Nanoparticle vaccines against dengue fever?

Every year more than 350 million people in over 120 countries contact dengue fever, which can cause symptoms ranging from aching muscles and a skin rash to life-threatening haemorrhagic fever. Researchers have struggled to create effective vaccines against dengue virus, … Continue reading

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Zoonotic Hepatitis E Virus

During the past ten years, several new hepatitis E viruses (HEVs) have been identified in various animal species. In parallel, the number of reports of indigenous hepatitis E in Western countries has increased as well, raising the question of what … Continue reading

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Herpesviruses as Pioneers in Cell Biology

Intracytoplasmic vesicular transport is well established; nucleo-cytoplasmic transport has so far been thought to be restricted to passage through the nuclear pore either passively, if size permits, or via karyopherin-mediated active transport. This limits transport in and out of the … Continue reading

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Closing in on the causes of host shutoff

When a virus enters a cell it relies on the molecular machinery of its host to help it replicate. In particular, the virus relies on the ribosomes in the host cell to translate viral messenger RNA (mRNA) into polypeptides. Many … Continue reading

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