Tag Archives: virus

Silencing the alarms: Innate immune antagonism by rotaviruses

This review discusses the structural and mechanistic basis of innate immune antagonism by two direct effectors, the Rotavirus NSP1 and VP3 proteins. It starts with a nice overview of Rotavirus biology then goes on to describe how the structural and … Continue reading

Posted in Microbiology | Tagged , , , , , , | Leave a comment

T cell exhaustion during persistent viral infections

Why does the immune system fail to clear some virus (and other infections) and allow a state of chronic infection to occur? Continue reading

Posted in Microbiology | Tagged , , , , , , , , | Leave a comment

Life in Our Phage World

“[the] molecular biology of higher organisms does not stand on the shoulder of giants, but on the shoulder of dwarfs like phage T4 and lambda.” Continue reading

Posted in Microbiology | Tagged , , , , , , | Leave a comment

HIV Rev – Really Exasperating Virus protein

Two papers provide a more detailed structural picture of how HIV Rev works. Continue reading

Posted in Microbiology | Tagged , , , , | Leave a comment

Paramyxovirus polymerase: transcription or replication?

How does the paramyxovirus polymerase decide on transcription or replication? Continue reading

Posted in Microbiology | Tagged , , , , , | 1 Comment

Coronavirus Cell Entry Requires Proteolysis of the S Protein

Different coronaviruses use different proteases to cleave the the S protein for cell entry. Continue reading

Posted in Microbiology | Tagged , , , , , | Leave a comment

Poliovirus replication – many generations per cell

Viruses with RNA genomes can multiply quickly, but not very accurately. This means that errors, or mutations, occur when the RNA is copied to create new viruses. The advantage of this rapid, but mistake-filled, RNA replication process is that some … Continue reading

Posted in Microbiology | Tagged , , , , , | Leave a comment

The arthropod origins of RNA viruses

A new paper in eLife describes the genetic diversity and novel genome structures of RNA viruses from arthopods, shedding new light on the ancestry and evolutionary history of plant and animal RNA viruses.   Unprecedented genomic diversity of RNA viruses … Continue reading

Posted in Microbiology | Tagged , , , , , | Leave a comment

Understanding Ebola Virus Transmission

This short review describes different routes of Ebola virus transmission between people. Continue reading

Posted in Microbiology | Tagged , , , , , , , , , | Leave a comment